影片讲述了一种新型致命病毒在几天之内席卷全球的故事。贝丝（格温妮丝·帕特洛 饰）从香港出差回明尼阿波利斯的家后突发疾病死亡，丈夫托马斯 （马特·达蒙 饰）协助米尔丝（ 凯特·温斯莱特饰）调查真相。可怕的是同样病症的患者在世界范围内大规模出现，病毒在不停蔓延。阴谋论记者艾伦（裘德·洛 饰）趁机散布对政...府和医疗机构不利的舆论。洛伦 （玛丽昂·歌迪亚·歌迪亚 饰）被派往香港调查病因，但却被本土医生扣留作为交换疫苗的人质。在Dr. Ellis Cheever （劳伦斯·菲什伯恩 饰）和年轻医生Ally Hextall（詹妮弗·艾莉 饰）的努力下，终于研制出治疗病毒的疫苗，事件终于得以平静。 值得一提的是本片还有港星何超仪和徐天佑的卖力出演。
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