明朝年间，宦官刘谨专权，利用锦衣卫残害忠良，忠良之后陆丹得各路英雄相助，并在古灵精怪的市井混混小子（尹天照饰）的误打误撞帮忙下，得以逃出生天，二人为避官兵追杀，误闯苗区，陆丹因此邂逅了美丽的苗族公主贝贝，两人一见钟情，不料贝贝兄长恨汉人入骨，在贝贝帮助下，小子与陆丹逃离苗区。陆丹入武当学武，小子则巧...遇刁蛮郡主菁照成一对欢喜冤家。刘谨欲杀正德皇帝篡位，正德受伤流落乡间，得酒家女李凤相救，后结识小子和陆丹，三人结拜为兄弟。正德与李凤相爱，想从此隐世，过一些平凡生活，不料刘谨用假皇帝兴风作浪，正德表明身份，却不被陆丹原谅，兄弟决裂。小子在苗区误创禁区而练成天蚕神功，助正德铲除奸党。陆丹为抱父仇，练成天蚕魔功，欲与小子决斗，，最后小子险胜，于是离开皇宫，与菁照携手天涯。
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