本剧是根据同名小说《战火中的青春》改编的。 1940年冬，日寇的铁蹄已经践踏了我国大片领土。冀中八路军某独立团被派出侦察连连长周剑峰乔装前往天津，刺杀日军设立在天津的生化研究所所长坂井一郎，并把爱国华侨捐献给根据地的一批珍贵药品运回根据地。天津医药界大亨唐云一直希望和富商张仲年家结为姻...亲，但章家公子章佩然对唐云之女唐蕊丝毫提不起兴趣，他一直暗恋着自己的着自己的大学同学童卉，而童卉对这个富家公子哥却有些厌恶。后来，章佩然追随着童卉来到了八路军冀中根据地。
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