本片根据蒲龄原著之《聊斋志异-画皮》一段改编而成,为武侠大导胡金铨在世的最后一部作品。落第书生王顺生娶妻多年,一无所出,一日自城中赶路回家时,偶遇一明艳照人之少妇尤枫尤自称身世可怜,被逼嫁入某大户人当妾待,正室所虐,故冒死出走,王仗义相助,愿意让尤暂居于其书齌,当晚王欲与尤行鱼水之欢,天忽亮,尤推说...身体不适,拒绝了王的要求。翌日,王往城中购胭脂水粉,欲赠尤以讨其欢心,遇玉清道人,后者指王邪气缠身,王置之不理。王返家,向妻子陈氏表明心意娶尤为妾,陈氏趁尤宽衣沐浴时,竟自窗外窥得尤下脸下脸皮,点画胭脂之骇人情景,吓得晕死过去,王连狂奔玉清道观,求道人除魔,玉清把一尘拂予王,嘱王把它挂在寝室门外,再作打算不料尤枫仍能潜入室内,向王申诉前生之辛酸遭遇。原来尤枫被一法力高强的阴阳法王所控制,用作诱饵残害人生。阴阳法王遂将王顺生杀害,并附于王顺生躯体到处伤人,幸得太乙上人和玉清道人师兄弟伸张正义,消灭了阴阳法正,救回了王顺生和尤枫,使他们得以转入转回……
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